HLA typing reads the tissue markers inherited from your parents that the immune system uses to tell self from non-self. Matching these markers between a patient and a possible donor shows how likely a transplanted organ or bone marrow is to be accepted rather than rejected.
Trusted by 1000+ families — results and counselling in your own language
Choose why you need typing and how many people are being tested. Your exact figure comes back within 1 hour of us seeing the case.
Patient plus every relative you want screened. Typing is charged per person; antibody and crossmatch tests only for the patient.
Your panel, at a glance
Indicative ranges only. Final cost depends on resolution level, number of family members typed, whether a crossmatch is repeated close to surgery and any desensitisation monitoring. We share an itemised estimate before you travel.
Next: tap through five loci and watch your match score change live
Two alleles are counted at each of five loci — that is the 10/10 every transplant unit talks about. Tap each locus to set how many of the two alleles match, and see honestly what that donor means.
Presents to killer T cells. A mismatch here raises both rejection and graft-versus-host risk.
The most polymorphic locus in the human genome — over 8,000 alleles. Hardest single locus to match.
Long ignored, now known to drive graft-versus-host disease and to control natural killer cell behaviour.
The single most important locus for graft survival in kidney transplant and for chronic GVHD in marrow.
Travels with DRB1 on the same haplotype. DQ antibodies are the commonest cause of late kidney graft loss.
Educational model only. Real donor selection also weighs allele- versus antigen-level mismatch, mismatch direction (host-versus-graft or graft-versus-host), donor age, sex, CMV status and antibody results.
The ideal marrow donor. Lowest acute and chronic graft-versus-host disease, best long-term survival, standard conditioning.
Ask about a 10/10 donorWho in your own family could actually be a donor?
You inherit one HLA haplotype from your mother and one from your father — call them A/B and C/D. Every child gets one from each side, so only four combinations exist. That is why a full sibling has exactly a 25% chance of being your identical twin immunologically, while a parent or child is always a half (haploidentical) match.
Identical to you
25% of siblings
Half match
25% of siblings
Half match
25% of siblings
No shared haplotype
25% of siblings
Even at 44%, the 56% case is not a dead end: a haploidentical parent, child or half-matched sibling with post-transplant cyclophosphamide is now a standard, well-proven transplant.
Type my familyMatching is only half the story. Transfusions, pregnancies and a previous transplant teach your immune system to recognise other people's HLA. cPRA is the single number that says what percentage of donors your antibodies would already reject — and it is the reason a perfectly matched donor can still fail the crossmatch.
What raises cPRA
Every blood or platelet transfusion
Each pregnancy (antibodies against the father's HLA)
A previous transplant, especially a failed graft
Ventricular assist devices and some vaccines, temporarily
Out of 100 random donors, 80 would be immunologically usable and 20 would be blocked by antibody.
Moderately sensitised
A workable donor is usually found within the family. Every candidate must be screened by virtual crossmatch before anyone travels.
What does that string of numbers on your lab report even mean?
Reports come back as strings like HLA-A*02:01:01:02L with no explanation. Paste any allele from your report and see exactly what each field means.
HLA-A*02:01:01:02L
Class I locus — presents to killer T cells, dominant in acute rejection and acute GVHD.
Field 1 — Allele group
Broad family, roughly the old serological antigen A2. This is all that low-resolution typing gives you.
Field 2 — Specific protein
The exact protein sequence. Two alleles differing here are a true mismatch and are counted in a 10/10 marrow match.
Field 3 — Synonymous DNA change
A silent coding difference — same protein, different DNA. Immunologically irrelevant for matching.
Field 4 — Non-coding change
A difference in an intron or untranslated region. Not relevant to matching.
Expression suffix
Low expression — the protein reaches the surface in reduced amounts.
Only the first two fields decide whether a donor is counted as matched. Everything after that is DNA detail that does not change the protein your immune system sees.
From the first WhatsApp message to post-transplant monitoring at home.
Patient plus every willing family member, with ages and blood groups. Send any old typing report, transfusion history and previous transplant details on WhatsApp — photos of paper reports are fine.
A transplant immunologist tells you which loci and which resolution you actually need, and which relatives are worth testing first. Nobody pays for a test that cannot change the plan.
6 mL EDTA blood per person, or a buccal swab kit couriered to you if travel is not yet possible. Samples are stable for 72 hours in transit at 4–25 °C.
NGS or SSP-PCR typing, with a parallel Luminex antibody screen for the recipient. Results are checked against family inheritance to confirm the haplotypes make genetic sense.
Recipient serum against donor cells by flow cytometry and CDC, plus a paper virtual crossmatch against every candidate donor so impossible pairs are removed before anyone travels.
A call in your language: who matches, how well, what the mismatch means for rejection or GVHD risk, and whether desensitisation is needed. You get the numbers, not a verdict.
The chosen donor route is priced end to end, with a hospital invitation letter for the medical visa — usually issued in 2–4 hours — for patient, donor and attendants together.
Serial DSA for organ recipients and STR chimerism for marrow recipients, reviewed remotely by the same team, so a problem is caught while it is still reversible.
These are typical figures from high-volume transplant programmes. Your own risk depends on age, diagnosis, conditioning regimen, antibody levels and how experienced the centre is with mismatched grafts.
HLA is inherited and fixed for life. One good high-resolution report can be reused for every future transplant, registry search or platelet request — keep the PDF safe. We archive yours too.
Every transfusion, pregnancy or failed graft can create new anti-HLA antibodies. DSA is repeated at set intervals and always within 2 weeks of surgery.
A mismatched allele only matters if your immune system has actually seen it. A mismatch with no corresponding antibody is far safer than a match with high-MFI DSA.
High DSA is treatable with plasmapheresis, IVIG and rituximab before surgery, monitored bead by bead. It adds around 2 weeks and cost — not impossibility.
No forms, no payment, no obligation. A transplant immunologist reads your existing typing or plans the right panel, tells you honestly who in the family is a realistic donor, and what it costs.
We reply on WhatsApp within 1 hour. Your reports are never shared with anyone else.
HLA typing usually means several relatives being tested together, and often two patients travelling later — recipient and donor. We handle the paperwork for all of them at once, and swab kits can be couriered to you before anyone flies.
"Four siblings were typed in one morning. The youngest was a full 10/10 match — we had been told for a year that no donor existed."
"My son's crossmatch with me was positive. They found the antibody, removed it over two weeks, and the transplant went ahead."
"The swab kit reached Tashkent in three days. By the time we landed the matching was already finished and the donor was chosen."
HLA (Human Leukocyte Antigen) molecules are the identity badges on your cells. Your immune system reads them constantly and attacks anything wearing the wrong badge. Typing reads the exact alleles you inherited — one set from each parent — so a transplant team can predict whether a graft will be accepted or rejected, whether donor immune cells will attack your body after a bone marrow transplant, and whether you already carry antibodies that make a particular donor unusable. Modern next-generation sequencing reads the gene letter by letter, so a '10/10 match' today means far more than the old serology-based match of twenty years ago.
No forms, no payment, no obligation. A transplant immunologist reads your existing typing or plans the right panel, tells you honestly who in the family is a realistic donor, and what it costs.
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